This hormone causes the adrenal glands to secrete cortisol. When the body is stressed, neurons release corticotrophin releasing factor (not corticotropin factor), which stimulates release of adrenocorticotropic hormone from the pituitary gland. One of the most powerful components in the development of depression is stress.

Physical activity can reduce depressive symptoms in persons without a clinical diagnosis of depression.

Many studies have shown that aerobic activity improves the response to pharmaceutical treatment in clinical depression.

There is compelling evidence that physical activity is beneficial in preventing and treating depression. Thoughts of death or suicide suicide attempts.Difficulty sleeping, early-morning awakening, or oversleeping.Difficulty concentrating, remembering, making decisions.Decreased energy, fatigue, being 'slowed down'.Loss of interest or pleasure in hobbies and activities.Feelings of guilt, worthlessness, helplessness.Persistent sad, anxious, or 'empty' mood.The National Institute of Mental Health describes the signs and symptoms of depression as:

According to the Center for Disease Control and Prevention, depression affects 1 in 10 American adults. Over an individual's lifetime, one may experience depressive symptoms without having a major depressive episode. A person may have one or repeated episodes over a lifetime. Major depression is defined as persistent (months long), profound blues or irritable mood, and loss of interest interfering with normal functioning.

Endorphin farms